Characterization of a human monoclonal antibody obtained after immunization with plasma vaccine and a booster with recombinant‐DNA hepatitis B vaccine
Identifieur interne : 000D66 ( Istex/Checkpoint ); précédent : 000D65; suivant : 000D67Characterization of a human monoclonal antibody obtained after immunization with plasma vaccine and a booster with recombinant‐DNA hepatitis B vaccine
Auteurs : R. A. Heijtink [Pays-Bas] ; J. Kruining [Pays-Bas] ; P. Van Bergen [Pays-Bas] ; S. De Rave [Pays-Bas] ; J. Van Hattum [Pays-Bas] ; M. Schutten [Pays-Bas] ; A. D. M. E. Osterhaus [Pays-Bas]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2002-03.
Abstract
A human monoclonal antibody type IgG4, designated 1Ff4, was obtained by Epstein Barr virus transformation of peripheral blood lymphocytes from a hepatitis B vaccinee (HB‐VAX: plasma‐derived vaccine) after one boost of yeast recombinant DNA derived vaccine (Engerix‐B). 1Ff4 binds preferentially to HBsAg/adw2 and HBsAg/ayw1. In binding experiments, it competes with antibodies induced by vaccination with HB‐VAX‐DNA (yeast recombinant) and HB‐VAX (plasma‐derived vaccine). 1Ff4 competes in part with a monoclonal antibody for the w/r region. Partial inhibition of binding of HBsAg/adw2 to solid phase anti‐HBs was detected, resembling inhibition obtained using other human monoclonal specific for the “a”‐loop. 1Ff4 does not bind to linear peptides covering the two “a”‐loops or to an adw2/G145R mutant, its binding to wild type HBsAg strongly depends on the presence of disulphide bonds. In a large series of HBsAg‐positive samples from an endemic area, 1Ff4 antibodies were successfully used to discriminate between an adw2 and an adrq+ strain. The characterisation of 1Ff4 and other human monoclonal anti‐HBs antibodies may help to understand the fine specificity of protective antibodies elicited by immunization. J. Med. Virol. 66:304‐311, 2002. © 2002 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.2146
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De Rave</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hepatology and Gastroenterology, Academic Hospital Dijkzigt, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Hattum, J" sort="Van Hattum, J" uniqKey="Van Hattum J" first="J." last="Van Hattum">J. Van Hattum</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Hepato‐gastroenterology, Academic Hospital Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Schutten, M" sort="Schutten, M" uniqKey="Schutten M" first="M." last="Schutten">M. 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Osterhaus</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Virology, Erasmus University Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">66</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="304">304</biblScope><biblScope unit="page" to="311">311</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A human monoclonal antibody type IgG4, designated 1Ff4, was obtained by Epstein Barr virus transformation of peripheral blood lymphocytes from a hepatitis B vaccinee (HB‐VAX: plasma‐derived vaccine) after one boost of yeast recombinant DNA derived vaccine (Engerix‐B). 1Ff4 binds preferentially to HBsAg/adw2 and HBsAg/ayw1. In binding experiments, it competes with antibodies induced by vaccination with HB‐VAX‐DNA (yeast recombinant) and HB‐VAX (plasma‐derived vaccine). 1Ff4 competes in part with a monoclonal antibody for the w/r region. Partial inhibition of binding of HBsAg/adw2 to solid phase anti‐HBs was detected, resembling inhibition obtained using other human monoclonal specific for the “a”‐loop. 1Ff4 does not bind to linear peptides covering the two “a”‐loops or to an adw2/G145R mutant, its binding to wild type HBsAg strongly depends on the presence of disulphide bonds. In a large series of HBsAg‐positive samples from an endemic area, 1Ff4 antibodies were successfully used to discriminate between an adw2 and an adrq+ strain. The characterisation of 1Ff4 and other human monoclonal anti‐HBs antibodies may help to understand the fine specificity of protective antibodies elicited by immunization. J. Med. 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Kruining</name><name sortKey="Osterhaus, A D M E" sort="Osterhaus, A D M E" uniqKey="Osterhaus A" first="A. D. M. E." last="Osterhaus">A. D. M. E. Osterhaus</name><name sortKey="Schutten, M" sort="Schutten, M" uniqKey="Schutten M" first="M." last="Schutten">M. Schutten</name><name sortKey="Van Bergen, P" sort="Van Bergen, P" uniqKey="Van Bergen P" first="P." last="Van Bergen">P. Van Bergen</name><name sortKey="Van Hattum, J" sort="Van Hattum, J" uniqKey="Van Hattum J" first="J." last="Van Hattum">J. Van Hattum</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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